Changes in the way research ethics was visualised in the wake of the Nuremberg Trials (1946), led to an atmosphere of protectionism of groups deemed to be vulnerable that was often legislated or regulated. This resulted in the relative underrepresentation of women in clinical trials. The position of women in research was further compromised in 1977, when in response to the tragedies resulting from thalidomide and diethylstilbestrol (DES), the United States Food and Drug Administration (FDA) prohibited women of child-bearing years from participation in early stage clinical trials. In practice this ban was often applied very widely to exclude all women. Women, at least those in the child-bearing years, were also deemed unsuitable research subjects due to their fluctuating hormonal levels during the menstrual cycle. However, research has demonstrated significant biological differences between the sexes in rates of susceptibility, symptoms and response to treatment in many major areas of health, including heart disease and some cancers. These exclusions pose a threat to the application of evidence-based medicine to women, and compromise to care offered to both women and men.
Fats contain both saturated and unsaturated (monounsaturated and polyunsaturated) fatty acids. Saturated fat raises blood cholesterol more than unsaturated fat, which may even help lower harmful cholesterol. Reducing saturated fat (most comes from meat, dairy and bakery products) to less than seven percent of total daily calories may help you reduce your cholesterol level. Whenever possible, replace saturated fat with monounsaturated and polyunsaturated fats.
Although creating financial incentives to lose weight isn't a new idea, now we know cashing in to stay motivated works long-term. In the longest study yet on this topic, Mayo Clinic researchers weighed 100 people monthly for one year, offering half the group $20 per pound lost plus a $20 penalty for every pound gained. Those in the monetary group dropped an average of nine pounds by the end of the year, while non-paid participants shed about two pounds. If you’re ready to gamble away weight, consider sites such as Healthywage, FatBet, or stickK.
It's still an open question, but there is no question that ALA represents a dietary difference between the sexes. For women, it's a healthful fat. For men with heart disease or major cardiac risk factors, it may also be a good choice — but men with more reason to worry about prostate cancer should probably get their omega-3s from fish and their vegetable fats largely from olive oil.